Long-Term Use Of Hormonal Contraceptives Leads To Glioma

Long-Term Use Of Hormonal Contraceptives Leads To Glioma.


The jeopardy for developing a scarce form of brain cancer known as glioma appears to go up with long-term use of hormonal contraceptives such as the Pill, creative Danish research suggests. Women under 50 with a glioma "were 90 percent more fitting to have been using hormonal contraceptives for five years or more, compared with women from the habitual population with no history of brain tumor," said study leader Dr David Gaist worldplusmed.com. However, the Danish sanctum couldn't prove cause-and-effect, and Gaist stressed that the findings "need to be put in context" for women because "glioma is very rare".



How rare? Only five out of every 100000 Danish women between the ages of 15 and 49 bloom the fit each year, according to Gaist, a professor of neurology at Odense University Hospital. He said that be featured includes women who assume contraceptives such as the birth control pill. So, "an overall risk-benefit evaluation favors continued use of hormonal contraceptives" antehealth.com. The findings were published online in the British Journal of Clinical Pharmacology.



In the study, Gaist's side looked at sway data on all Danish women between the ages of 15 and 49 who had developed a glioma between 2000 and 2009. In all, investigators identified 317 glioma cases, surrounded by whom nearly 60 percent had worn a contraceptive at some point. They then compared them to more than 2100 glioma-free women of equivalent ages, about half of whom had used contraceptives. Use of the Pill or other hormonal contraceptive did appear to protuberance up the risk for glioma, the researchers reported, and the risk seemed to improve one's lot with the duration of use.



For example, women who had used any type of hormonal birth control for less than one year had a 40 percent greater endanger for glioma compared with non-users. And those who had used the upper for five years or more saw their risk nearly double compared to non-users, the findings showed. In addition, Gaist's band found that glioma risk seemed to go up most sharply for women who had used contraceptives containing the hormone progestogen, rather than estrogen.



Dr Evan Myers is a professor of obstetrics and gynecology at Duke University Medical Center in Durham, NC He described the Danish turn over as "really well-done". The look couldn't back a cause-and-effect relationship between hormonal contraception use and hazard for glioma. Myers also suggested that future research focus on a number of indirect factors - such as the progesterone found in some types of IUDs (intrauterine devices) - that might also show a critical role in driving up glioma risk.



And in the end, "even if hormonal contraception does enhancement the relative risk of glioma, the authoritative risk - the actual increase in the chances of having a glioma diagnosed - is unequivocally small". According to his own statistical breakdown, Myers said that between 2000 and 2011, glioma laid hold of less than two out of every 100000 American women between the ages of 15 and 29.



So "To put that in sentiment that's about one-tenth the risk of death from trauma in women aged 15 to 44, and a youthful over twice the risk of dying from a complication of pregnancy". Myers said his number-crunching suggests an even debase risk profile when looking specifically at women who are taking the Pill or another form of hormonal contraception rvtl anti-aging treatment and equinox. "Without universal through the math, it's about 8,5 cases of glioma per million" for that subset of women.

tag : glioma women hormonal contraceptives gaist danish myers compared findings

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