The Same Gene Is Associated With Obesity And Dementia

The Same Gene Is Associated With Obesity And Dementia.

A variation of the obesity-related gene FTO may escalation the risk of Alzheimer's disease and dementia, finds a unique Swedish study. Previous research has shown that the FTO gene affects body rally index (BMI), levels of leptin (a hormone involved in appetite and metabolism), and the chance for diabetes read this. All vascular risk factors that have also been linked with the risk of Alzheimer's disease.

This imaginative study, conducted by the Karolinska Institute in Stockholm, included more than 1000 Swedish people, elderly 75 and older, who were followed for nine years example here. They all underwent genetic testing at the start of the study.

Participants who carried an AA gene unstable in the FTO gene had a 58 percent increased gamble of developing Alzheimer's and a 48 percent increased risk for dementia, compared to those without the variant. The researchers also said the jeopardy could be 100 percent higher for a person with the FTO-AA variant and a gene transmutation called APOE4, which is the highest-risk variant of the known Alzheimer's-related gene called APOE.

So "One of the intriguing aspects of the results is that the increased endanger was independent of the traits previously associated with FTO, such as paunchiness and diabetes measured at baseline," wrote Dr Caroline Graff and colleagues at the Karolinska Institute, in a statement release. "Our results suggest that the mechanism by which FTO is associated with an increased danger for Alzheimer's and dementia may be different from how it increases the risk for obesity".

The study was slated to be presented July 12 at the Alzheimer's Association International Conference on Alzheimer's Disease. "This is a fascinating primeval finding, which fits with the known connections between nature health and brain health," Maria Carrillo, major director of medical and scientific relations at the Alzheimer's Association, said in an league news release "However, we do need to see these results confirmed by other researchers".

tag : alzheimer increased study dementia obesity results variant percent disease

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Dr. Alejandra Falto

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