A New Method For Treating Stubborn Hypertension

A New Method For Treating Stubborn Hypertension.


A untried proposition to blast away kidney nerves has a striking effect on lowering blood pressure in resolution patients whose blood pressure wasn't budging despite trying multiple drugs, Australian researchers report. Although this sanctum only followed patients for a short time - six months - the authors allow the approach, which involves delivering radiofrequency energy to the so-called "sympathetic " nerves of the kidney, could have an force on heart disease and even help lower these patients' gamble of death recommended reading. The findings were presented Wednesday at the annual meeting of the American Heart Association in Chicago and published simultaneously in The Lancet.



The muse about was funded by Ardian, the company that makes the catheter widget used in the procedure. "This is an extremely important study, and it has the potential for in effect revolutionizing the way we deal with treatment-resistant hypertension," said Dr Suzanne Oparil, director of the Vascular Biology and Hypertension Program at the University of Alabama at Birmingham for more info. Oparil spoke at a message talk Wednesday to announce the findings, though she was not involved in the study.



Treatment-resistant blood pressure, defined as blood on that cannot be controlled on three drugs at full doses, one of which should be a diuretic, afflicts about 15 percent of the hypertensive population. "Many patients are boisterous on four or five drugs and have truly refractory hypertension. If it cannot be controlled medically, it carries a pongy cardiovascular risk".



This radioablation procedure had already successfully prevented hypertension in beastlike models. According to study author Murray Esler, the machination specifically targets the kidneys' sympathetic nerves. Previous studies have indicated that these nerves are often activated in benevolent hypertension a cardiologist and scientist at the Baker IDI Heart and Diabetes Institute in Melbourne, Australia.



All of the participants in this work were taking at least three blood pressure medications and many were on five for more than five years. Despite this, their blood intimidation stubbornly refused to go below 160 mm Hg systolic (the superb reading). In fact, the average blood pressure in the team was 178 mm Hg systolic. Normal systolic blood pressure is less than 120.



The mode involves inserting a catheter into the kidney via the groin. About 100 men and women old 18 to 85 were randomly assigned to undergo the procedure and keep taking their medication, or to unpretentiously stay with their drugs. Blood pressure measurements taken in a doctor's office went down by 32/12 mm Hg which was "a very marked effect".



They did not change in the control group, but stayed at 178/97 mm Hg. Several patients apothegm their systolic blood pressure wander below 140. Readings bewitched at home were not as dramatic. The reasons for this are unclear. The procedure was also found to be safe, with no hurt to the kidneys and no blood clots, at least for the six months of the study.



A number of questions remain, including whether the secure is lasting, whether the nerves will grow back and whether this approach would be as effective in non-white populations or in mobile vulgus with diabetes or metabolic syndrome or even those with lower starting blood pressures. The approach, which is already clinically accessible in Australia and Europe, will be tested in the United States starting next year. "I have been asked if this can heal hypertension," Esler concluded. "that's a big task. As a young man 40 years ago that was my dream, curing hypertension more help. Now we have a signet moving in that direction but curing hypertension is presumably still a dream".

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