New Ways Of Treating Prostate Cancer And Ovarian Cancer

New Ways Of Treating Prostate Cancer And Ovarian Cancer.


New scrutinization supports different ways to treat ovarian and prostate cancer, while producing a let-down for those with a certain form of colon cancer. Both the ovarian and prostate cancer trials could trade clinical practice, with more women taking the drug bevacizumab (Avastin) to combat the disease in its advanced stages and more men getting emission therapy for locally advanced prostate cancer, according to researchers who presented the findings Sunday at the American Society of Clinical Oncology (ASCO) annual appointment in Chicago gothenburg. A third trial, looking at the effectiveness of cetuximab (Erbitux) in treating established colon cancer patients, found the narcotic made little difference to their survival.



The first study found that adding Avastin to post chemotherapy (carboplatin and paclitaxel) and continuing with "maintenance" Avastin after chemo truly slowed the time-to-disease recurrence in women with advanced ovarian cancer. Avastin is an anti-angiogenic drug, message it interferes with a tumor's blood supply additional reading. "This is the first molecular-targeted and first anti-angiogenesis remedial programme to demonstrate benefit in this population and, combined with chemotherapy followed by Avastin maintenance, should be considered as one footing option for women with this disease," said lead researcher Dr Robert A Burger, chief of the Women's Cancer Center at Fox Chase Cancer Center in Philadelphia.



So "This is a budding potential treatment paradigm for stage 3 and 4 ovarian cancer," added Dr Jennifer Obel, an attending medical doctor at Northshore University Health System and chairperson of a Sunday news conference at which these results were presented. The phase 3 reflect on involved almost 1,900 women with stage 3 and stage 4 ovarian cancer. Those who received banner chemotherapy plus Avastin, and then maintenance Avastin, for up to 10 months lived just over 14 months without their disability progressing compared with about 10 months for those receiving standard chemotherapy alone.



Those who received chemo bonus Avastin but no maintenance drug lived without a recurrence for 11,3 months, a contrariety not considered statistically significant. "I'm cautiously optimistic about this data. It evidently shows that those who had maintenance Avastin had improved profession-free survival," said Dr Robert Morgan, co-director of the gynecologic oncology program at City of Hope Cancer Center in Duarte, Calif. "I suppose we have to hold-up for longer term outcomes before we make definite conclusions. It's too advanced for overall survival benefit data".



However, he pointed out, a four-month difference for progression-free survival is "substantial". Doctors are already using Avastin off-label substantially to treat ovarian cancer although it is not yet approved for this use. It has been shown to be more energetic in this cancer than in many cancers for which it is approved.



A second phase 3 memorize presented Sunday found that adding radiation to hormone therapy, also known as androgen-deprivation therapy (ADT) in patients with locally advanced or high-risk prostate cancer reduced the seven-year jeopardy of fading by 43 percent compared to treating with hormone therapy alone. "We know that dispersal is better if added to ADT, but we didn't know if we could treat patients with ADT alone. The essence here is that radiation is an indispensable element in the treatment of high-risk prostate cancer patients".



In the Canadian study, more than 1,200 men were randomized to notified of either hormone therapy alone or hormone therapy with radiation. Over the next seven years, those in the league group had a 43 percent lower risk of moribund from prostate cancer, the team found. "After seven years, 74 percent of patients with the combined curing were alive as compared to 66 percent in the ADT group alone," well-known study author Dr Padraig Warde, deputy head of the radiation medicine program at the University of Toronto's Princess Margaret Hospital. "At seven years, only 10 percent of patients who received diffusion and ADT had died of prostate cancer vs 21 percent in the ADT-alone group".



And "Patients treated with the combined therapy - shedding and hormones - be longer and are less likely to die of prostate cancer. Radiation treatments should be part of the healing package for this group of patients". Also, radiation doses are higher today and may be even more potent.



Finally, yet another aspect 3 study - albeit one with less encouraging results - found that the monoclonal antibody deaden cetuximab (Erbitux) did not aid people with (potentially curable) early-stage colon cancer if they carried the reasonable form of the KRAS gene. The finding was a blow, given that Erbitux has helped patients with more advanced cancers. Patients in this ponder had the normal form of the KRAS gene, for which the drug shop in more advanced cancer.



The more than 1600 patients in the study were followed for almost 16 months and were also treated with conventional chemotherapy. "Much to our surprise, the fling showed that patients receiving standard therapy compared to those receiving cetuximab with customary therapy had no difference in outcomes," said study author Dr Steven Alberts, a professor of oncology at the Mayo Clinic College of Medicine in Rochester, Minn. "It also indicates that c murrain in earlier stages may be unusual than diseases in later stages" found it for you. The trial, which was supported by the US National Institutes of Health, Bristol-Myers Squibb, ImClone, Sanofi-Aventis and Pfizer, was halted after researchers realized there was no added benefit.

tag : cancer patients avastin therapy prostate ovarian advanced study alone

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