The 2009 H1N1 Virus Is Genetically Changed Over The Past 1,5 Years

The 2009 H1N1 Virus Is Genetically Changed Over The Past 1,5 Years.


Although the pandemic H1N1 "swine" flu that emerged remain pop has stayed genetically established in humans, researchers in Asia say the virus has undergone genetic changes in pigs during the latest year and a half. The fear is that these genetic changes, or reassortments, could put together a more virulent bug. "The particular reassortment we found is not itself likely to be of major charitable health risk, but it is an indication of what may be occurring on a wider scale, undetected," said Malik Peiris, an influenza superb and co-author of a paper published in the June 18 issue of Science lean muscle. "Other reassortments may occur, some of which present greater risks".



The findings underscore the importance of monitoring how the influenza virus behaves in pigs who is easy chair and professor of microbiology at the University of Hong Kong and regulated director of the university's Pasteur Research Center link. "Obviously, there's a lot of evolution going on and whenever you consult some unstable situation, there's the potential for something new to emerge that could be dangerous," added Dr John Treanor, professor of medicament and of microbiology and immunology at the University of Rochester Medical Center in New York.



The untested H1N1 pandemic influenza virus that began circulating in humans in at daybreak 2009 originally came from swine, first infecting humans in Mexico before spreading to more than 200 countries. In humans, the 2009 H1N1 virus has stayed genetically the same and still causes somewhat gentle disease, when it causes disease at all (the virus has all but disappeared in recent weeks, although experts distrust it will be back). But in January 2010, the authors of this paper isolated a rejuvenated version of the H1N1 virus in pigs in a Hong Kong slaughterhouse.



The H1N1 virus circulating in humans ostensibly looped back to pigs, where it underwent this genetic change. Theoretically, the changed virus could now caper back to humans, potentially causing more dangerous disease. "We found that the pandemic virus has recurrently transmitted back to pigs, and we report one instance of reassortment, meaning genetic change, of this virus within pigs".



Peiris and his co-authors apiculate out that the influenza viruses that sparked the 1918, 1957 and 1968 pandemics all lingered in mammals before reassorting and wreaking despoliation on humans. "Our point is that this is likely to be occurring in many places and not only to Hong Kong. There is need for much greater surveillance efforts to assess what is occurring on a worldwide basis. In the past, we have focused a lot of notoriety trying to understand what's been effective on in birds this site. This article and others are saying it may be equally or more important to have extensive surveillance of viruses in pigs".

tag : virus humans genetic influenza genetically university occurring disease pandemic

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