Scientists Have Discovered New Genes Associated With Alzheimer's Disease

Scientists Have Discovered New Genes Associated With Alzheimer's Disease.


Researchers shot that they have spotted two unique regions of the human genome that may be related to the situation of Alzheimer's disease. The findings, published in the June issue of the Archives of Neurology, won't replace the lives of patients or people at risk for the devastating dementia just yet, however male enhancement. "These are now uncharted biological pathways to start thinking about in terms of finding drug targets and figuring out what unquestionably causes Alzheimer's disease," explained study senior author Dr Jonathan Rosand, a liberty member with the Center for Human Genetic Research at Massachusetts General Hospital and an collaborator professor of neurology at Harvard Medical School in Boston.



Maria Carrillo, senior supervisor of medical and scientific relations at the Alzheimer's Association, believes findings such as this one will eventually usher in an age of "personalized medicine" for Alzheimer's, much like what is being seen now with cancer get more information. "Perhaps some day in the future, all this information can be put into a scuttle and given a bar code, which represents your risk for Alzheimer's," she said, while cautioning, "we're not there yet".



Although scientists have known that Alzheimer's has a graphic genetic component, only one gene - APOE - has been implicated and in early-onset disease. A few weeks ago, however, two studies identified three genetic regions associated with Alzheimer's disease. Now Rosand and his colleagues have looked at genetic and neuroimaging statistics on the wisdom structures of 168 rank and file with "probable" Alzheimer's disease (Alzheimer's can't be definitively diagnosed until a wit autopsy has been conducted), 357 people with mild cognitive vitiation and 215 normal individuals.



So "Basically, they were looking to see if some of the imaging results were changed in commoners with Alzheimer's disease who also had these types of genetic variations". The study confirmed that APOE is still the chief gene when it comes to Alzheimer's, while the three more recently identified regions seemed to have an additive effect.



In addition, the authors "found two different areas that were associated with some of the MRI changes of Alzheimer's contagion that hadn't been implicated in previous studies of Alzheimer's". The next step is to take out what these genes do.



Right now, scientists only know that "they encode proteins that are involved with the wen of neurons, the integrity of neurons and the function of neuronal transmission, but beyond that we don't know. It's very material that these types of genes are localized and fleshed out, and that the basic biology of why they are making changes is discovered" this site. In combining to predicting risk, the genetic variants could be potential targets for both prevention and curing of Alzheimer's, although that's way down the line.

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