Another Genetic Cause Of Alzheimer's Disease

Another Genetic Cause Of Alzheimer's Disease.


Researchers have discovered that the anomaly of a gene associated with untimely onset Alzheimer's may block a key recycling process indispensable for brain cell survival - a finding that points the way to possible treatment for the disease astoria. When it's working properly, this gene - called presenilin 1 (PS1) - performs a momentous house-cleaning advantage by helping brain cells digest unwanted, damaged and potentially toxic proteins.



But in its mutated form, the gene fails to advise cells recycle these the toxins, suggesting an explanation for the damage to the brain characteristic of Alzheimer's disease paurush. "We credence in we have identified the principal mechanism by which mutations of PS1 cause the most common genetic tone of Alzheimer's disease," study co-author Dr Ralph A Nixon, professor in the departments of psychiatry and chamber biology as well as director of NYU's Center of Excellence on Brain Aging and the Silberstein Alzheimer's Institute, said in a university low-down release.



And "Presently, no effective treatment exists to either disinclined or prevent the progression of Alzheimer's disease," added Nixon, also director of the Center for Dementia Research at the Nathan S Kline Institute for Psychiatric Research in New York City. "This idea has the potency of identifying such a treatment".



Mutations of the PS1 gene have previously been thought to wax production of the toxic beta amyloid protein that appears to collect in the brains of Alzheimer's patients. In turn, scientists have theorized that by preventing amyloid deposits from accumulating, they might be able to progressive or bar Alzheimer's progression.



However, the current investigation into PS1 behavior side-steps this potential scenario - without questioning its validity - by focusing on the feasibility that abnormal PS1 function may cause cell expiry unconnected to beta amyloid buildup. PS1 mutations and other factors could, therefore, exalt Alzheimer's in entirely different ways, the team said.



So "There is an urgent need now to fathom Alzheimer's disease as caused by multiple factors and approach the treatment from that perspective," said Nixon, who added that the reported finding opens up a new target for Alzheimer's interventions down the road. Focusing on how to put back brain cells' normal recycling system is a promising therapeutic approach since its disruption appears to boost Alzheimer's biye bari te anti k jor kore chudlo. Nixon and his colleagues report their findings in the June 10th online pour of the journal Cell.

tag : alzheimer disease brain treatment nixon amyloid cells mutations approach

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