Breast Cancer Treatment Tablets For Osteoporosis

Breast Cancer Treatment Tablets For Osteoporosis.

The bone analgesic zoledronic acid (Zometa), considered a potentially heartening weapon against breast cancer recurrence, has flopped in a revitalized study involving more than 3360 patients. The drug, long used to disagreement bone loss from osteoporosis, did not appear to prevent breast cancer from returning or to boost disease-free survival overall device. British researchers presented the insufficient findings Thursday at the San Antonio Breast Cancer Symposium in Texas.

And "As a whole, the chew over is negative," study author Dr Robert Coleman, a professor of medical oncology at the University of Sheffield in England, said during a Thursday scoop colloquium on the findings enlargement. "There is no overall difference in recurrence rates or survival rates between patients who got the bone pharmaceutical and those who did not, except in older patients, defined as more than five years after menopause".

That was a possible aglow spot in the results. "In that population, there is a benefit". The older women had a 27 percent amelioration in recurrence and a 29 percent improvement in overall survival over the five-year follow-up, compared to those who didn't get the drug.

And "There was tremendous belief that this drug approach would be a major leap forward. There have been other trials that suggest this is the case". In one earlier study, the use of the drug was linked with a 32 percent progress in survival and lowered recurrence in younger women with breast cancer. Other research has found that hale women on bone drugs were less prone to develop breast cancer, so experts were hoping the drugs had an anti-tumor effect.

Zometa, marketed by Novartis AG, is one of a year of drugs used to treat osteoporosis and also to save pain when cancers have spread to the bone - in part, by slowing bone erosion caused by the disease. It is given intravenously, while other bisphosphonates such as Actonel, Fosamax or Boniva can be charmed orally.

In the trial, known as AZURE (Adjuvant Treatment with Zoledronic Acid in State II/III Breast Cancer), Coleman and his colleagues evaluated 3,360 core cancer patients from 174 participating centers, all with organize II or III cancers but no averment of metastases (cancer that has spread beyond the original site). About half received the bone drugs bonus standard therapy; half just got standard therapy.

The focus was on disease-free survival. After five years, about 400 women in each collection either died or had recurrences. When Coleman's tandem looked at subgroups, however, they found the benefit among older women, a pronouncement they say warrants more study. "The younger patients are getting no benefit. If anything, they are doing a sparse bit worse".

In addition, there were some troubling side effects among women taking Zometa, including 17 cases of osteonecrosis of the jaw (a wicked bone disease that can result in death of the jawbone). Dr Sharon Giordano, an partner professor of breast medical oncology at the University of Texas MD Anderson Cancer Center, was not affected in the study but put it in perspective.

Bisphosphonates have been used to treat osteoporosis as well as bone complications of heart of hearts cancer treatment. "The role of bisphosphonates in preventing cancer recurrence has been less clear," she said, noting that multiple studies have had conflicting findings. As for the advance found in postmenopausal women "I would believe this hypothesis-generating and not practice-changing".

Other studies underway may provide a clearer answer. Since the prevalent study was presented at a meeting, its findings should be considered preliminary until published in a peer-reviewed journal. Said Coleman: "Zoledronic acid cannot be routinely recommended for prohibition of cancer returning, but it remains a very pure drug for patients where the cancer has already spread to the bone" order minipress. Coleman disclosed receiving tub-thumper fees from Novartis; the researchers also received academic grant funding from the drug maker.

tag : cancer breast women study patients coleman recurrence survival osteoporosis

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Dr. Alejandra Falto

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