The Use Of Nicotinic Acid In The Treatment Of Heart Disease

The Use Of Nicotinic Acid In The Treatment Of Heart Disease.

Combining the vitamin niacin with a cholesterol-lowering statin remedy appears to make patients no profit and may also increase side effects, a new study indicates. It's a inferior result from the largest-ever study of niacin for heart patients, which involved almost 26000 people niconot commercial. In the study, patients who added the B-vitamin to the statin deaden Zocor saw no added advance in terms of reductions in heart-related death, non-fatal heart attack, stroke, or the need for angioplasty or alternative surgeries.

The study also found that people taking niacin had more incidents of bleeding and (or) infections than those who were taking an serene placebo, according to a team reporting Saturday at the annual meeting of the American College of Cardiology, in San Francisco. "We are saddened that these results did not show benefits for our patients," study lead author Jane Armitage, a professor at the University of Oxford in England, said in a rendezvous news release "Niacin has been Euphemistic pre-owned for many years in the belief that it would help patients and prevent heart attacks and stroke, but we now understand that its adverse side effects outweigh the benefits when used with current treatments".

Niacin has long been in use to boost levels of "good" HDL cholesterol and decrease levels of "bad" LDL cholesterol and triglycerides (fats) in the blood in colonize at risk for heart disease and stroke. However, niacin also causes a covey of side effects, including flushing of the skin. A drug called laropiprant can truncate the incidence of flushing in people taking niacin. This new study included patients with narrowing of the arteries.

They received either 2 grams of extended-release niacin increased by 40 milligrams of laropiprant or equivalent placebos. All of the patients also took Zocor (simvastatin). The patients from China, the United Kingdom and Scandinavia were followed for an standard of almost four years.

Besides showing no reassuring effect on heart health outcomes, the team noted that people taking niacin had about the same amount of heart-related events (13,2 percent) as those who took a placebo a substitute (13,7 percent). Side property were common. As already reported online Feb 26, 2013 in the European Heart Journal, by the end of the study, 25 percent of patients taking niacin gain laropiprant had stopped their treatment, compared with 17 percent of the patients taking a placebo.

And "The paramount reason for patients stopping the care was because of adverse side effects, such as itching, rashes, flushing, indigestion, diarrhea, diabetes and muscle problems," Armitage said at the spell in a journal news release. "We found that patients allocated to the conjectural treatment were four times more likely to stop for skin-related reasons, and twice as liable to to stop because of gastrointestinal problems or diabetes-related problems". Patients taking niacin and laropiprant had a more than fourfold increased imperil of muscle pain or weakness compared to the placebo group, the team noted.

Did the offence lie with the laropiprant and not niacin? Armitage is doubtful. She pointed to a prior trial, called AIM-HIGH, which was discontinued antiquated in 2011 when researchers found no benefit to niacin treatment. At the time, some experts said that the smaller citizenry in AIM-HIGH masked any sign of benefit, but Armitage said the unusual trial's much bigger study group confirms that niacin probably does not help.

Speaking in February 2013 at the rhythm of the journal's release of niacin's safety profile, one US expert was less than impressed by niacin's performance. The essay "confirms that, for the present moment, there may be little additional promote with the use of niacin when patients are well treated with the lipid-lowering statin drugs," said Dr Kevin Marzo, ringleader of cardiology at Winthrop-University Hospital in Mineola, NY. He said that the results of the additional trial, along with those from a prior large study, "now may put the final nail in the coffin on niacin-based strategies to stir up HDL and lower cardiovascular events".

Other tried-and-true approaches may work best. "In combining to statins, our focus should be on continued lifestyle changes such as a Mediterranean diet, complemented with every day exercise". The US Food and Drug Administration had been waiting on the new nuisance results to decide whether to approve niacin/laropiprant for use against heart disease vigrx top. But in December 2012, responding to preceding findings, drug maker Merck said it no longer planned to press for permission from the FDA and in January 2013 delayed niacin/laropiprant from markets worldwide.

tag : niacin patients heart study laropiprant percent people placebo armitage

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